Omeprazole is a proton pump inhibitor (PPI) used to reduce the amount of acid produced in the stomach. It is commonly prescribed for conditions caused by excess stomach acid.
Brand names: Prilosec (US), Losec (outside US), and generics
Available forms: Capsules, tablets (including delayed-release), oral suspension
Prescription & OTC: Both forms available, depending on dosage and indication
✅ Common Uses of Omeprazole
Condition
Effect
Gastroesophageal reflux disease (GERD)
Reduces acid reflux and heartburn
Peptic ulcers
Heals stomach and duodenal ulcers
H. pylori eradication (in combination)
Part of triple therapy with antibiotics
Zollinger-Ellison syndrome
Treats excessive acid production from tumors
Erosive esophagitis
Promotes healing of inflamed esophagus
NSAID-induced ulcers
Prevents or treats ulcers caused by non-steroidal anti-inflammatory drugs
🧬 How It Works
Omeprazole blocks the proton pump (H⁺/K⁺ ATPase enzyme) in the stomach lining, which is the final step in acid production. This:
Decreases stomach acidity
Reduces irritation and promotes healing
Provides relief from acid-related symptoms like heartburn
💊 Dosage & Administration
Indication
Common Dose
GERD (adults)
20 mg once daily for 4–8 weeks
Gastric ulcer
20 mg once daily for 4–8 weeks
Duodenal ulcer
20 mg once daily for 2–4 weeks
H. pylori infection
20 mg twice daily (with antibiotics) for 10–14 days
Zollinger-Ellison syndrome
60 mg or more daily (adjusted as needed)
OTC heartburn relief
20 mg once daily for up to 14 days
Important: Take 30–60 minutes before meals, usually in the morning.
